The Big-five is a collective taxonomy that describes the personality of individuals. Personality is central to every human behaviour and indeed refers to differences in characteristics pattern of thinking, feeling, behaving and preferences in life. The objective of this study was to determine relationships of Big-five personality variables and sport preferences among student-athletes in Universities in North East Zone, Nigeria. The study was carried out using correlational research design. Six hundred and seventeen (617) student athletes were purposively selected that participated in Pre-NUGA competition. Data collected was analysed using descriptive statistics of mean and standard deviation and Pearson Product Moment Correlation at 0.05 level of significance. The result of the study shows that all the Big-five personality variables (Extraversion, conscientiousness, openness to experience, agreeableness and neuroticism) have significant positive relationship with sport preference. The study concluded that most student athletes in Universities in North East Zone, Nigeria, made sport preference in accordance with their personality types. It was therefore recommended that sports psychologist in Universities in North East Zone, Nigeria should provide guidance and counselling for student athletes in other to enable them make correct choice of sport that would match their personality characteristics.