There is usually a trauma on the health of surviving partners on the early death of spouses. This study investigated the cause of early mortality of spouses in Ogun State, Nigeria. Two thousand surviving spouses who were below 50 years of age were selected for the study, using a purposive sampling technique. The instrument for data collection was on Cause of Death Inventory. Demographic characteristics of the respondents were obtained. Age of respondent and that of the deceased at the time of death, sex, occupation and the cause of early death of respondents’ spouses were analyzed using Percentages. The study found that the main cause of early death of spouses in Ogun State was sudden death/cardiac arrest (42.8%), followed by accident 644(32.2%),terminal illness 296(14.8%), witchcraft 84(4.2%),(858), genotype (SS) 48(2.4%), suicide 28(1.4%), carelessness 32(1.6%) and hereditary 12(06%). The study recommended that people should be going for regular medical checkup even when they are not sick, consult their physician when they notice any strange things or feelings in their body, avoid anger, worry and take life generally easy. People should avoid violations of safety rules and alcohol consumption when driving. They should not over work, rather, engage in regular exercises, rest when fatigued and be very close to their creator by praying fervently.